Premier Downtown Greenville SC Hotels

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Alardo Riojas

Updated: 22 January 2024 · 3 min

Nestled in the very heart of South Carolina, Greenville is a hidden gem waiting to be discovered by travelers from all walks of life. This charming city, known for its rich history, vibrant culture, and stunning natural beauty, offers an array of accommodations that cater to both the luxury seeker and the budget-conscious. Among these, downtown Greenville SC hotels stand out for their prime locations, offering guests a gateway to exploring the city's bustling streets, quaint shops, and eclectic dining options.

Choosing the right hotel in downtown Greenville can significantly enhance your travel experience, placing you mere steps away from the iconic Falls Park on the Reedy, the peace center, and the unique Liberty Bridge. These accommodations range from opulent boutique hotels to cozy inns, each boasting amenities and services tailored to make your stay as comfortable and memorable as possible. Recommendations for downtown stays often highlight not just the quality of service and accommodation but also the immersive experience of being at the heart of Greenville’s cultural and social vibrancy.

Insights into downtown Greenville SC hotels reveal a fascinating aspect of the city’s hospitality scene: a commitment to blending Southern charm with modern convenience. Whether you’re in town for business, a romantic getaway, or a family vacation, the central district hosts an array of hotels that promise to meet your needs and exceed your expectations. With this guide, we invite you to explore the best downtown Greenville SC hotels, where each stay tells a story, and every guest becomes a part of the city’s unfolding narrative.
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Our Top 5

(Sorted by rating & number of reviews)

1. Super 8 By Wyndham Greenville
2. Express Inn & Suites
3. Holiday Inn Express Hotel & Suites Greenville, An Ihg Hotel
4. Hampton Inn & Suites Greenville
5. Motel 6-Greenville, Tx

Downtown Greenville SC Hotels for the Business Traveler

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Greenville
Dec 30, 2025 - Dec 31, 2025

Super 8 By Wyndham Greenville

5.8

Good

(84 Reviews)

+ 25 photos
Super 8 by Wyndham Greenville is a budget-friendly hotel that doesn’t skimp on comfort and accessibility. This hotel is ideal for leisure travelers looking for an economical stay without sacrificing convenience to downtown Greenville’s attractions. Guests can enjoy free breakfast, Wi-Fi, and comfortable rooms, ensuring a pleasant stay. Its proximity to local dining and shopping venues makes it a desirable spot for those eager to experience Greenville’s local flavor.
Address: 5010 Business Highway 69 South
Rating: Good 5.8 (84 Reviews)
Rooms: 52
Price: From 64$

Express Inn & Suites

5.1

Good

(190 Reviews)

+ 7 photos
Express Inn & Suites offers a straightforward, comfortable stay for those looking to explore Greenville and its surroundings. Though more aligned with simplicity, the hotel provides all the necessary amenities for a restful night's sleep after a day of touring. Its location offers convenient access to local attractions, making it a practical choice for travelers who prioritize exploration and ease. The friendly staff, clean rooms, and complimentary breakfast add to the value, making it a solid option for those who want a no-fuss base for their Greenville adventures.
Address: 1215 East Interstate 30
Rating: Good 5.1 (190 Reviews)
Rooms: 40
Price: From 62$

Downtown Greenville SC Hotels for Leisure Travelers

Leisure travelers seeking to immerse themselves in the charm and vibrancy of Greenville will find that downtown hotels offer unparalleled access to the city's rich cultural tapestry and leisure activities. These hotels not only serve as comfortable retreats after a day of exploration but also as gateways to Greenville's scenic parks, unique shops, and culinary delights. From luxurious boutiques offering personalized services to family-friendly stays with amenities for all ages, downtown Greenville SC hotels cater to a diverse array of tastes and preferences, ensuring every vacation is memorable.

Holiday Inn Express Hotel & Suites Greenville, An Ihg Hotel

7.9

Good

(85 Reviews)

+ 72 photos
Strategically positioned to offer both ease of access to downtown Greenville and the peace required for concentration, the Holiday Inn Express Hotel & Suites stands out for business travelers. This hotel is renowned for its spacious rooms that provide a tranquil retreat for work, with desks and free high-speed internet. Guests can start their day with a complimentary Express Start breakfast, featuring a range of healthy and indulgent options. The fitness center and indoor pool offer opportunities to relax or recharge after a productive day. Additionally, the hotel's proximity to local businesses and attractions makes it an ideal choice for those looking to blend work with some leisure exploration.
Address: 2901 Mustang Crossing
Rating: Good 7.9 (85 Reviews)
Rooms: 80
Price: From 105$

Hampton Inn & Suites Greenville

8.5

Good

(90 Reviews)

+ 91 photos
The Hampton Inn & Suites Greenville is a beacon for business travelers seeking both convenience and comfort in downtown Greenville. Located just minutes from major business hubs, this hotel boasts modern rooms equipped with ergonomic workstations and free Wi-Fi, ensuring that guests can work comfortably anytime. The on-site business center and meeting spaces cater to all professional needs, from impromptu meetings to presentations. After work, guests can relax in the outdoor pool or take a short walk to explore downtown's dining and entertainment options. Mornings at the Hampton are kick-started with a complimentary hot breakfast, perfect for the busy professional on the go.
Address: 3001 Kari Lane
Rating: Good 8.5 (90 Reviews)
Rooms: 75
Price: From 109$

Motel 6-Greenville, Tx

6.5

Good

(193 Reviews)

+ 44 photos
Motel 6-Greenville might not be in downtown Greenville but it represents the Motel 6 brand's commitment to providing affordable lodging without compromising on basic comfort. For travelers passing through or those with plans around the greater Greenville area, this hotel offers clean, modern rooms at a price point that’s hard to beat. The hotel’s pet-friendly policy and the presence of amenities like free Wi-Fi make it a good pick for casual visitors looking for straightforward accommodation.
Address: 5109 Interstate 30
Rating: Good 6.5 (193 Reviews)
Rooms: 89
Price: From 67$